Background: Primary lateral sclerosis (PLS) is an idiopathic upper motor neuron
degenerative disorder. The aim of this study was to compare brain volumes in patients with …

BACKGROUND AND PURPOSE: Recent evidence from neuropsychologic and
neuroimaging studies suggests that central nervous system involvement in amyotrophic …

BACKGROUND AND PURPOSE: Primary lateral sclerosis (PLS) is a rare form of motor
neuron disease characterized by upper motor neuron dysfunction. Because pathologic …

To determine longitudinal rates of cortical atrophy in classical Amyotrophic lateral sclerosis
(ALS) and ALS variants. Rates of cortical thinning were determined between 2 scans, 3–15 …

Objective: The clinical diagnosis of primary lateral sclerosis can only be made after upper
motor neuron symptoms have progressed for several years without developing lower motor …

Objective To identify the nature and prevalence of cognitive and behavioral abnormalities in
patients with amyotrophic lateral sclerosis (ALS). Design Survey of clinical characteristics …

Objectives Amyotrophic lateral sclerosis (ALS) is a fatal disease characterised by combined
upper and lower motor neuron degeneration. An early and accurate diagnosis is important …

Background Widespread cortical atrophy in Amyotrophic Lateral Sclerosis (ALS) has been
described in neuropathological studies. The presence of cortical atrophy in conventional …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …