This paper reviews clinical evidence suggesting that antagonism of the N‐methyl‐d‐
aspartate subtype of glutamate receptors by ethanol may convey an important component of …

Long-term alcohol exposure leads to the development of alcohol dependence, which is
possibly induced by changes in specific neurotransmitter functions. Accumulating evidence …

Long-term alcohol exposure may lead to development of alcohol dependence in
consequence of altered neurotransmitter functions. Accumulating evidence suggests that the …

NMDA receptors are glutamate-gated ion channels, mediating excitatory neurotransmission
in the brain. These widely distributed receptors are known to play a role in neuronal …

Alcohol addiction is a costly and detrimental chronic relapsing disorder, characterized by
compulsive alcohol use despite the negative consequences; it is thought to be associated …

Long-term alcohol exposure gives rise to development of physical dependence on alcohol
in consequence of changes in certain neurotransmitter functions. Accumulating evidence …

OBJECTIVE: A family history of alcoholism is a risk factor for the development of ethanol
dependence. Ethanol is an antagonist of the N-methyl-d-aspartate (NMDA) glutamate …

Data from behavioral studies also fit well with the electrophysiological and biochemical data.
In drug discrimination experiments, rats and pigeons that have been trained to respond to …

Ethanol is a small molecule acting on several neurotransmitter systems in the brain.
Accumulating evidences suggest that the primary excitatory-ie the glutamatergic …

Ethanol is an antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor. Ethanol
dependence upregulates NMDA receptors and contributes to crosstolerance with selective …