Hypoxia has for many years been acknowledged to be a characteristic physiological
abnormality in solid tumours. It arises primarily because the tumour microcirculation that …

Tumors are characterized by an inefficient and disorganized vasculature which leads to
tumor regions that are transiently or chronically undersupplied with oxygen (hypoxia) and …

Most histopathological classifications of human cancers include significant numbers of
hypoxic cells. There is increasing evidence that, at least in certain types of human solid …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and
even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but …

Tumour hypoxia is a major constraint for radiotherapy and many types of chemotherapy. A
variety of different pathogenetic mechanisms contribute to the development of hypoxia in …

Since the 1950s, the presence of hypoxic cells in human tumours has been widely regarded
as a problem, and a variety of strategies have been developed and tested, both in …

In radiobiology, the hypoxic cells have been shown to be more resistant to irradiation as
compared to cells irradiated in conditions of normal oxygenation. Moreover, most solid …

Since observations from the beginning of the last century, it has become well established
that solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas …

Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of
aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be …