Regulation of pharmacology by hetero-oligomerization between A1 adenosine receptor and P2Y2 receptor
T Suzuki, K Namba, H Tsuga, H Nakata - Biochemical and biophysical …, 2006 - Elsevier
Adenosine and ATP/UTP are main components of the purinergic system that modulate
cellular and tissue functions via specific adenosine and P2 receptors, respectively. Here, we …
cellular and tissue functions via specific adenosine and P2 receptors, respectively. Here, we …
[HTML][HTML] Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains
K Yoshioka, R Hosoda, Y Kuroda, H Nakata - FEBS letters, 2002 - Elsevier
Adenosine and ATP modulate cellular and tissue functions via specific P1 and P2 receptors,
respectively. Although, in general, adenosine inhibits excitability and ATP functions as an …
respectively. Although, in general, adenosine inhibits excitability and ATP functions as an …
Heteromeric association creates a P2Y-like adenosine receptor
K Yoshioka, O Saitoh, H Nakata - Proceedings of the …, 2001 - National Acad Sciences
Adenosine and its endogenous precursor ATP are main components of the purinergic
system that modulates cellular and tissue functions via specific adenosine and ATP …
system that modulates cellular and tissue functions via specific adenosine and ATP …
Functions of heteromeric association between adenosine and P2Y receptors
H Nakata, K Yoshioka, T Kamiya, H Tsuga… - Journal of molecular …, 2005 - Springer
It is now well accepted that G protein-coupled receptors (GPCRs) can be directly associated,
as either homo-or hetero-oligomers, to alter their functions. G protein-coupled purinergic …
as either homo-or hetero-oligomers, to alter their functions. G protein-coupled purinergic …
ATP-and adenosine-mediated signaling in the central nervous system: purinergic receptor complex: generating adenine nucleotide-sensitive adenosine receptors
K Yoshioka, H Nakata - Journal of pharmacological sciences, 2004 - Elsevier
Abstract Adenosine A 1 receptors (A 1 R) are able to form a heteromeric complex with P2Y 1
receptors (P2Y 1 R) that generates A 1 R with P2Y 1 R-like agonistic pharmacology. A …
receptors (P2Y 1 R) that generates A 1 R with P2Y 1 R-like agonistic pharmacology. A …
[HTML][HTML] Immunogold electron microscopic evidence of in situ formation of homo- and heteromeric purinergic adenosine A1 and P2Y2 receptors in rat brain
K Namba, T Suzuki, H Nakata - BMC Research Notes, 2010 - Springer
Background Purines such as adenosine and ATP are now generally recognized as the
regulators of many physiological functions, such as neurotransmission, pain, cardiac …
regulators of many physiological functions, such as neurotransmission, pain, cardiac …
[HTML][HTML] Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling
A Lillo, E Martínez-Pinilla, I Reyes-Resina… - International journal of …, 2020 - mdpi.com
The aim of this paper was to check the possible interaction of two of the four purinergic P1
receptors, the A2A and the A3. Discovery of the A2A–A3 receptor complex was achieved by …
receptors, the A2A and the A3. Discovery of the A2A–A3 receptor complex was achieved by …
Regulation of A1 adenosine receptor functioning induced by P2Y1 purinergic receptor activation in human astroglial cells
I Tonazzini, ML Trincavelli, M Montali… - Journal of …, 2008 - Wiley Online Library
In the rat brain, a heteromeric association between adenosine A1 and purinergic P2Y1
receptors has been demonstrated. It is suggested that this association plays an important …
receptors has been demonstrated. It is suggested that this association plays an important …
[HTML][HTML] Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor
Interaction of the rat A 3 adenosine receptor (A 3 AR) with G-proteins has been assessed
using a stably transfected Chinese hamster ovary cell system. The non-selective AR agonist …
using a stably transfected Chinese hamster ovary cell system. The non-selective AR agonist …
Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist‐specific G protein activation
Y Cordeaux, AP IJzerman, SJ Hill - British journal of …, 2004 - Wiley Online Library
The present study investigates the effect of varying ligand structure on the ability of agonists
to activate guanine nucleotide‐binding proteins of the Gi, Gs and Gq families via the A1 …
to activate guanine nucleotide‐binding proteins of the Gi, Gs and Gq families via the A1 …