▪ Abstract Signaling roles for phosphoinositides that involve their regulated hydrolysis to
generate second messengers have been well characterized. Recent work has revealed …

PtdIns (3, 5) P 2 was discovered about a decade ago and much of the machinery that
makes, degrades and senses it has been uncovered. Despite this, we still lack a complete …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …

Abstract Phosphatidylinositol-4, 5-bisphosphate (PI (4, 5) P 2) is an important signaling lipid
and plays a crucial role in a wide variety of cellular processes by interacting with protein …

Phosphoinositides play a major role in cellular signaling and membrane organization.
During the last three decades we have learned that enzymes turning over phosphoinositides …

The lipid products of phosphoinositide 3-kinase (PI3K) are involved in many cellular
responses such as proliferation, migration and survival. Disregulation of PI3K-activated …

The enormous versatility of phosphatidylinositol as a mediator of intracellular signalling is
due to its variable phosphorylation on every combination of the 3′, 4′ and 5′ positions …

The polyphosphorylated inositol lipids are essential for the transduction of signals generated
by cell surface receptors [1-4] and play important roles in regulating membrane trafficking …