Highlights•ECM signaling in morphogenesis and tissue repair.•ECM signals with
mechanically liberated or exposed biologically active sites.•ECM signals via proteolysis or …

The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation,
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …

The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

During normal morphogenesis the extracellular matrix (ECM) influences cell motility,
proliferation, apoptosis, and differentiation. Tissue engineers have attempted to harness the …

The extracellular matrix (ECM) consists of a complex mixture of structural and functional
macromolecules and serves an important role in tissue and organ morphogenesis and in the …

Normal tissue development and function are regulated by the interplay between cells and
their surrounding extracellular matrix (ECM). The ECM provides biochemical and …

Extracellular matrix (ECM) proteins constitute> 1% of the proteome and interact with many
modifiers and growth factors to affect most aspects of cellular behaviour during development …

The extracellular matrix (ECM) is a meshwork of both structural and functional proteins
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …

Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Within native tissues cells are held within the extracellular matrix (ECM), which has a role in
maintaining homeostasis, guiding development and directing regeneration. Efforts in tissue …