Publisher Summary This chapter discusses eukaryotic DNA methylation and gene
expression. The methylation of DNA in animal cells is a postreplicative process involving the …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA
methylation patterns that are required for proper epigenetic regulation of gene expression …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Since it was discovered, there was an increased interest in the analysis and the
quantification of DNA methylation. In mammals this modification of DNA occurs mainly at …

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …

Publisher Summary Deoxyribonucleic acid (DNA) methylation, a covalent modification of the
genome, is emerging as an important player in the regulation of gene expression. This …

Epithelial to mesenchymal transition (EMT) occurs during the pathological process
associated with tumor progression and is considered to influence and promote the …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Cancer is a leading cause of death worldwide. Aberrant promoter hypermethylation of CpG
islands associated with tumor suppressor genes can lead to transcriptional silencing and …