The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …

Cancer development and progression is dictated by a series of alterations in genes such as
oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an …

DNA methylation/demethylation constitutes a major consequence in all biological processes
involving transcription, differentiation, development, DNA repair, recombination, and …

The unique properties of a cancer cell are acquired through a stepwise accumulation of
heritable changes in the information content of proto‐oncogenes and tumor suppressor …

DNA methylation is a post-replicative, or epigenetic, modification of the genome that is
critical for proper mammalian embryonic development, gene silencing, X chromosome …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale international …

DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …

Cancer is characterised by DNA hypermethylation and gene silencing of CpG island-
associated promoters, including tumour-suppressor genes. The methyl-CpG-binding domain …

Decades of investigation on DNA methylation have led to deeper insights into its metabolic
mechanisms and biological functions. This understanding was fueled by the recent …

DNA methylation plays a critical role in the regulation of chromatin structure and gene
expression and is involved in a variety of biological processes. The levels and patterns of …