Abnormal renovascular resistance and glomerular filtration rate are characteristic of
established hypertension and may also be involved in its pathogenesis. To determine renal …

Relationships between renal haemodynamics and the renin-angiotensin system were
examined in 128 male adolescents with differing predispositions to hypertension. Baseline …

Background: Few studies have examined to what extent genes might modulate the changes
of systolic and diastolic blood pressure (BP) with age although, in older populations, systolic …

There is increasing evidence that a major site of production of angiotensin I and II is
peripheral tissue. Both angiotensin I and II are present in venous blood in amounts far too …

1. Almost all the factors that may cause a rise in blood pressure are, in turn, influenced by
the increase in blood pressure per se. Thus any primary involvement of one or more of these …

It has been proposed that a reduction in the number of nephrons is a renal abnormality that
plays an important role in the pathogenesis of essential hypertension. The objective of this …

Low-renin hypertension, representing roughly one quarter of all essential hypertension, is
widely recognized by distinct physiological features, including salt-sensitivity, diuretic …

Objective Renin–angiotensin system gene polymorphisms are associated with essential
hypertension; angiotensinogen gene variants are considered potential genetic risk factors …

After 100 years of measurement, reasons for interindividual and populational variation in
blood pressure have proven difficult to identify. Use of 24-hr blood pressure monitoring has …

Abstract Background and Methods. The kidney is important in blood-pressure regulation, but
its role in the development of essential hypertension is still subject to debate. We compared …