Inhibition of the DNA damage response (DDR) enhances therapeutic effects of DNA-
damaging cancer therapies by blocking induction of DNA repair and driving cancer cells to …

Free radicals play a key role in many physiological decisions in cells. Since free radicals are
toxic to cellular components, it is known that they cause DNA damage, contribute to DNA …

Inhibitors of the nuclear DNA damage sensor and signalling enzyme poly (ADP-ribose)
polymerase (PARP) have recently been introduced in the therapy of cancers deficient in …

The DNA damage response (DDR) system consists of complex signalling pathways that
secure the integrity of the genome in eukaryotic cells. DDR pathway activation follows …

This chapter entitled “Perspectives in ROS/Redox Regulation Cancer Therapy” discusses
the status of redox regulation anticancer therapy, its lacunae, and what needs to be done …

Increasing evidence demonstrates that DNA damage and genome instability play a crucial
role in ageing. Mammalian cells have developed a wide range of complex and well …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Control of redox homeostasis is crucial for a number of cellular processes with deregulation
leading to a number of serious consequences including oxidative damage such induction of …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …

The importance of the efficient detection, signaling and activation of cell cycle checkpoints,
particularly following the formation of lethal DNA double-strand breaks (DSB) generated …