The Swedish mutation of amyloid precursor protein (APP-sw) has been reported to
dramatically increase beta amyloid production through aberrant cleavage at the beta …

Transcription of the gene encoding amyloid precursor protein (APP) varies in a cell-specific
and developmentally regulated manner. The 5′ region of this gene possesses a high …

The hallmark of Alzheimer's disease (AD) pathology is an accumulation of amyloid β (Aβ)
and phosphorylated tau, which are encoded by the amyloid precursor protein (APP) and …

Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular
amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding …

In our previous studies, significant hypermethylation of the sirtuin 1 (SIRT1) gene and
demethylation of the β-amyloid precursor protein (APP) gene were found in patients with …

Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder
and shows progressive memory loss and cognitive decline. Intraneuronal filaments …

Alzheimer's disease (AD) is a chronic neurodegenerative disease and mitochondrial
impairment is a key feature of AD. The mitochondrial DNA (mtDNA) epigenetic mechanism is …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

Alzheimer's disease (AD) is a multifactorial disorder induced by a combination of genetic
and environmental factors, and epigenetic modifications could be the key to understand the …