With recent developments of molecular biomimetics that combine genetic engineering and
nanotechnology, peptides can be genetically engineered to bind specifically to inorganic …

Elucidating the structure–activity relationships between biomolecules and hydroxyapatite
(HAP) is essential to understand bone mineralization mechanisms, develop HAP-based …

The genesis of bone and teeth involves highly coordinated processes, which involve
multiple cell types and proteins that direct the nucleation and crystallization of inorganic …

The regeneration of mineral crystals under physiological conditions is an efficient way to
repair defects in hard tissues. To achieve robust mineralization on surfaces such as the tooth …

Enamel biomineralization is modulated by biological macromolecules composed of amino
acids. Although previous studies have shown that single amino acids, poly-amino acids and …

We report selection and characterization of hydroxyapatite-binding heptapeptides from a
peptide− phage library and demonstrate the effects of two peptides, with different binding …

Apatite-binding peptides discovered by phage display provide an alternative design method
for creating functional biomaterials for bone and tooth tissue repair. A limitation of this …

The global burden of bone-related diseases is increasing in the aging society; thus,
improved bone targeted imaging for their early identification and treatment are needed. In …

Hydroxyapatite (HA), the principal component of bone mineral, shows osteoconductive
properties when employed for coating metal implants as well as scaffold materials in …

The challenges in engineering bone scaffolds reflect the complexity of bone as an organ.
The organic-inorganic hybrid system design aims to provide signals within a conductive …