The existence of functionally distinct T lymphocyte subsets in man, initially demonstrated
with heteroantisera, has been confirmed with monoclonal reagents. Two major subsets have …

The generation of IgM-and IgG-secreting cells in the human autologous MLR has been
confirmed by using a microwell culture system and a reverse hemolytic plaque assay. The …

The induction of immunoglobulin (Ig) synthesis in the autologous MLR has an absolute
requirement for helper/inducer (Leu-3) T cells, whereas an excess of suppressor/cytotoxic …

We analyzed the effect of 2 hybridoma monoclonal antibodies (Mab), D1-12 and D4-22, with
specificity for common determinants of human Ia molecules, on the mixed lymphocyte …

Highly purified populations of human peripheral blood macrophages, null, B, and T
lymphocytes, and mixed populations of B plus null cells were compared for their ability to act …

This study was directed at determining the major histocompatibility complex (MHC) antigens
recognized by helper (Leu-3) and suppressor-cytotoxic (Leu-2) T lymphocyte subsets in …

The autologous mixed lymphocyte reaction (AMLR) is a proliferative response of T cells to
signals from autologous non-T cells. The AMLR has been an enigma to immunologists …

Two major subsets of human T lymphocytes that are functionally analogous to the mouse Lyt-
2+ and Lyt-2-subsets have been defined by their expression of two thymus-dependent …

Abstract Although Leu-2+(OKT8+) T cells activated in the mixed lymphocyte reaction (MLR)
mediate both alloantigen-specific cytotoxicity and suppression of alloantigen-induced …

The regulation of B-cell and T-cell immune responses has been extensively examined and
in the experimental animal appears to involve regulatory or suppressor T cells (1-4). The …