Ca2+‐dependent induction of TRPM2 currents in hippocampal neurons

ME Olah, MF Jackson, H Li, Y Perez… - The Journal of …, 2009 - Wiley Online Library
TRPM2 is a Ca2+‐permeable member of the transient receptor potential melastatin family of
cation channels whose activation by reactive oxygen/nitrogen species (ROS/RNS) and ADP …

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

D McHugh, R Flemming, SZ Xu, AL Perraud… - Journal of Biological …, 2003 - ASBMB
TRPM2 is a member of the melastatin-related TRP (transient receptor potential) subfamily. It
is expressed in brain and lymphocytes and forms a cation channel that is activated by …

TRPM2 cation channels, oxidative stress and neurological diseases: where are we now?

M Nazıroğlu - Neurochemical research, 2011 - Springer
Abstract The Na+ and Ca 2+-permeable melastatin related transient receptor potential 2
(TRPM2) channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+ or by …

Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat

KKH Chung, PS Freestone… - Journal of …, 2011 - journals.physiology.org
Transient receptor potential melastatin 2 (TRPM2) channels are sensitive to oxidative stress,
and their activation can lead to cell death. Although these channels have been extensively …

The role of TRPM channels in cell death

S McNulty, E Fonfria - Pflügers Archiv, 2005 - Springer
Transient receptor potential (TRP) channels of the melastatin-like family (TRPM) play critical
roles in mediating cellular responses to a wide range of physiological stimuli that, under …

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

J Du, J Xie, L Yue - Proceedings of the National Academy of …, 2009 - National Acad Sciences
Melastatin-related transient receptor potential channel 2 (TRPM2) is a Ca2+-permeable,
nonselective cation channel that is involved in oxidative stress-induced cell death and …

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function

ZZ Mei, HJ Mao, LH Jiang - American Journal of Physiology …, 2006 - journals.physiology.org
TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …

Trpm2

M Faouzi, R Penner - … Transient Receptor Potential (TRP) Cation Channels …, 2014 - Springer
TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM)
family of cation channels. The protein is widely expressed including in the brain, immune …

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …

A key role for Mg2+ in TRPM7's control of ROS levels during cell stress

HC Chen, LT Su, O González-Pagán… - Biochemical …, 2012 - portlandpress.com
The TRPM7 (transient receptor potential melastatin 7) channel has been shown to play a
pivotal role in cell survival during brain ischaemia as well as in the survival of other cell …