Solvent-free synthesis, in vitro and in silico studies of novel potential 1, 3, 4-thiadiazole-based molecules against microbial pathogens

IA Shehadi, MT Abdelrahman, M Abdelraof… - Molecules, 2022 - mdpi.com
A new series of 1, 3, 4-thiadiazoles was synthesized by the reaction of methyl 2-(4-hydroxy-3-
methoxybenzylidene) hydrazine-1-carbodithioate (2) with selected derivatives of …

Utility of Bis‐Hydrazonoyl Chlorides as Precursors for Synthesis of New Functionalized Bis‐Thiadiazoles as Potent Antimicrobial Agents

SM Gomha, MS El_Gendy… - Journal of …, 2018 - Wiley Online Library
N′, N ″‐([1, 1'‐Biphenyl]‐4, 4′‐diyl) bis (2‐oxopropanehydrazonoyl chloride) is
considered to be the key intermediate for the synthesis of a variety bis‐1, 3, 4‐thiadiazole …

Synthesis, antimicrobial evaluation and molecular docking of new functionalized bis (1, 3, 4-thiadiazole) and bis (thiazole) derivatives

HK Mahmoud, AA Abbas, SM Gomha - Polycyclic aromatic …, 2021 - Taylor & Francis
Abstract Many bis-1, 3, 4-thiadiazoles 7, 10a, b, 13a-c and bis-thiazoles 16a-d, 19a-d were
synthesized from reaction of bis (hydrazonoyl) chloride 4 with a series of methyl …

Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity

AO Abdelhamid, IE El Sayed, YH Zaki, AM Hussein… - BMC chemistry, 2019 - Springer
Background Pyrazolines show different biological activities. In recent years, interest in the
chemistry of hydrazonoyl halides has been renewed. 1, 3, 4-Thiadiazoles are one of the …

New 1, 3, 4‐thiadiazole derivatives: synthesis, characterization, and antimicrobial activity

AM Abo‐Bakr, HE Hashem - Journal of heterocyclic chemistry, 2019 - Wiley Online Library
In the present study, 2, 5‐bis (mercapto‐acetichydrazide)‐1, 3, 4‐thiadiazole (1) was utilized
by different reagents, namely, ethoxymethylene malononitrile, ethoxymethylene ethyl …

Synthesis, characterization and molecular docking studies of highly functionalized and biologically active derivatives of 2-aminothiazole

G Kanagasabapathy, S Britto, V Anbazhagan - Journal of Molecular …, 2023 - Elsevier
Many derivatives of 2-aminothiazoles are found to have significant biological properties and
used as potential antibacterial and antifungal drugs. Therefore new synthetic methodologies …

Synthesis and biological evaluation of new 1, 3, 4-thiadiazole derivatives as potent antimicrobial agents

MG Kamel, FM Sroor, AM Othman… - Monatshefte für Chemie …, 2022 - Springer
Abstract A series of 1, 3, 4-thiadiazole derivatives were designed and synthesized using N-
(4-nitrophenyl) acetohydrazonoyl bromide and 1-[3, 5-dimethyl-1-(4-nitrophenyl)-1 H …

Efficient synthesis, antibacterial, antifungal, antioxidant and cytotoxicity study of 2‐(2‐hydrazineyl) thiazole derivatives

VA Adole, RA More, BS Jagdale, TB Pawar… - …, 2020 - Wiley Online Library
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …

New and efficient approach for synthesis of novel bioactive [1, 3, 4] thiadiazoles incorporated with 1, 3-thiazole moiety

TA Farghaly, MA Abdallah, GS Masaret… - European Journal of …, 2015 - Elsevier
Abstract A series of novel 1, 3, 4-thiadiazoles incorporated with thiazole moiety was
synthesized by reaction of 5-acetyl-2-benzoylimino-3-phenyl-1, 3, 4-thiadiazole …

Synthesis, characterization and anti-microbial activities of novel thiazole derivatives.

G Saravanan, V Alagarsamy, TGV Pavitra, GC Kumar… - 2010 - cabidigitallibrary.org
In the present study, a novel thiazoles were synthesized by incorporation of pyrazole moiety
at 2nd position of 2-hydrazinyl-N-(4-phenylthiazol-2-yl) acetamide (5) by treating with …