Effects of a novel orally administered calpain inhibitor SNJ‐1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis
N Trager, A Smith, G Wallace IV… - Journal of …, 2014 - Wiley Online Library
Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin‐specific T
cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro …
cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro …
A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis
GW Hassen, J Feliberti, L Kesner, A Stracher… - Journal of …, 2006 - Elsevier
Aberrant activation of calpain plays a key role in the pathophysiology of several
neurodegenerative disorders. Calpain is increasingly expressed in inflammatory cells in …
neurodegenerative disorders. Calpain is increasingly expressed in inflammatory cells in …
Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis
MK Guyton, A Das, S Samantaray… - Journal of …, 2010 - Wiley Online Library
Experimental autoimmune encephalomyelitis (EAE) is an animal model for studying multiple
sclerosis (MS). Calpain has been implicated in many inflammatory and neurodegenerative …
sclerosis (MS). Calpain has been implicated in many inflammatory and neurodegenerative …
A novel combination approach to effectively reduce inflammation and neurodegeneration in multiple sclerosis models
A Haque, NNM Trager, JT Butler, A Das… - Neurochemistry …, 2024 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease characterized by immune-mediated
attacks on the central nervous system (CNS), resulting in demyelination and recurring T-cell …
attacks on the central nervous system (CNS), resulting in demyelination and recurring T-cell …
Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis
GW Hassen, J Feliberti, L Kesner, A Stracher… - Brain research, 2008 - Elsevier
Axonal injury is the major correlate of permanent disability in neurodegenerative diseases
such as multiple sclerosis (MS), especially in secondary-progressive MS which follows …
such as multiple sclerosis (MS), especially in secondary-progressive MS which follows …
[HTML][HTML] The involvement of calpain in CD4+ T helper cell bias in multple sclerosis
N Trager, JT Butler, A Haque, SK Ray… - Journal of clinical & …, 2013 - ncbi.nlm.nih.gov
The pathogenesis of multiple sclerosis (MS) is mediated by massive infiltration of myelin-
specific T cells into the central nervous system (CNS). Self-reactive CD4+ T helper (Th) cells …
specific T cells into the central nervous system (CNS). Self-reactive CD4+ T helper (Th) cells …
Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis
DC Shields, WR Tyor, GE Deibler… - Proceedings of the …, 1998 - National Acad Sciences
In demyelinating diseases such as multiple sclerosis (MS), myelin membrane structure is
destabilized as myelin proteins are lost. Calcium-activated neutral proteinase (calpain) is …
destabilized as myelin proteins are lost. Calcium-activated neutral proteinase (calpain) is …
Activation of calpain and caspase pathways in demyelination and neurodegeneration in animal model of multiple sclerosis
A Das, MK Guyton, JT Butler, SK Ray… - CNS & Neurological …, 2008 - ingentaconnect.com
Experimental autoimmune encephalomyelitis (EAE), a widely recognized animal model of
multiple sclerosis (MS), is highly useful for studying inflammation, demyelination, and …
multiple sclerosis (MS), is highly useful for studying inflammation, demyelination, and …
Inhibition of calpain attenuates encephalitogenicity of MBP‐specific T cells
MK Guyton, S Brahmachari, A Das… - Journal of …, 2009 - Wiley Online Library
Multiple sclerosis (MS) is a T‐cell mediated autoimmune disease of the CNS, possessing
both immune and neurodegenerative events that lead to disability. Adoptive transfer (AT) of …
both immune and neurodegenerative events that lead to disability. Adoptive transfer (AT) of …
Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease
K Schaecher, A Rocchini, J Dinkins, DD Matzelle… - Journal of …, 2002 - Elsevier
Calpain activity and expression at the protein level were examined in inflammatory cells,
activated microglia, and astrocytes prior to or at onset of symptomatic experimental allergic …
activated microglia, and astrocytes prior to or at onset of symptomatic experimental allergic …