To study the molecular pharmacology of low-voltage–activated calcium channels in
biophysical detail, human medullary thyroid carcinoma (hMTC) cells were investigated using …

The voltage gated calcium channel family is a major target for a range of therapeutic drugs.
Mibefradil (Ro 40–5967) belongs to a new chemical class of these molecules which differs …

Mibefradil is a tetralol derivative chemically distinct from other calcium channel antagonists.
It is a very effective antihypertensive agent that is thought to achieve its action via a higher …

In contrast to other kinds of voltage-gated Ca2+ channels, the underlying molecular basis of
T-type and R-type channels is not well-understood. To facilitate comparisons with cloned …

Mibefradil is a novel Ca2+ antagonist which blocks both high‐voltage activated and low
voltage‐activated Ca2+ channels. Although L‐type Ca2+ channel block was demonstrated …

The structural determinants of mibefradil inhibition were analyzed using wild-type and
inactivation-modified Ca V 1.2 (α1C) and Ca V 2.3 (α1E) channels. Mibefradil inhibition of …

We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues,
and mibefradil using recombinant T-and L-type Ca2+ channels expressed separately in …

Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated
Ca2+ channels. We previously showed that block of high-voltage-activated channels by …

Mechanism of voltage- and use-dependent block of class A Ca2+ channels by mibefradil Page
1 Mechanism of voltage- and use-dependent block of class A Ca2+ channels by mibefradil 1S …

ABSTRACT NNC 55‐0396 is a structural analog of mibefradil (Ro 40‐5967) that inhibits
both T‐type and high‐voltage‐activated (HVA) Ca2+ channels with a higher selectivity for T …