Toll-like receptor modulators: a patent review (2006–2010)
Introduction: The immune response is mediated via two parallel immune components, innate
and adaptive, whose effector functions are highly integrated and coordinated for the …
and adaptive, whose effector functions are highly integrated and coordinated for the …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
Toll-like receptor agonists: a patent review (2011–2013)
WM Hussein, TY Liu, M Skwarczynski… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Toll-like receptors (TLRs) are a crucial part of the innate immunity and present
the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 …
the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 …
Recent progress in the development of Toll-like receptor (TLR) antagonists
ABSTRACT Introduction: Pattern recognition receptors (PRRs) of the innate immune system
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
New developments in Toll-like receptor targeted therapeutics
DJ Connolly, LAJ O'Neill - Current opinion in pharmacology, 2012 - Elsevier
Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …
significant amount of evidence implicates TLRs in the pathogenesis of immune diseases …
Prophylactic and therapeutic implications of toll‐like receptor ligands
M Hedayat, K Takeda, N Rezaei - Medicinal research reviews, 2012 - Wiley Online Library
The evolutionary conserved Toll‐like receptors (TLRs) are the first identified and best
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
Toll-like receptors as targets for immune disorders
B Keogh, AE Parker - Trends in Pharmacological Sciences, 2011 - cell.com
Since the identification of the first Toll-like receptor (TLR) in humans in 1997, understanding
of the molecular basis for innate immunity has increased significantly. The TLR family and …
of the molecular basis for innate immunity has increased significantly. The TLR family and …
TLR based therapeutics
A Dunne, NA Marshall, KHG Mills - Current opinion in pharmacology, 2011 - Elsevier
Toll-like receptors (TLRs) play a crucial role in innate immune responses to infection.
Binding of agonists to TLRs promotes maturation of antigen presenting cells, such as …
Binding of agonists to TLRs promotes maturation of antigen presenting cells, such as …
TLR agonists as modulators of the innate immune response and their potential as agents against infectious disease
EJ Mifsud, ACL Tan, DC Jackson - Frontiers in immunology, 2014 - frontiersin.org
Immunotherapies that can either activate or suppress innate immune responses are being
investigated as treatments against infectious diseases and the pathology they can cause …
investigated as treatments against infectious diseases and the pathology they can cause …
The future of toll-like receptor therapeutics.
T Parkinson - Current opinion in molecular therapeutics, 2008 - europepmc.org
Since the discovery of human TLRs, manipulating the activity of these receptors to modulate
immune responses for therapeutic purposes has initiated intense activity in the …
immune responses for therapeutic purposes has initiated intense activity in the …