[HTML][HTML] Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

VN Ivanov, J Wu, TK Hei - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The
challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of …

[HTML][HTML] Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells

VN Ivanov, J Wu, TJC Wang, TK Hei - Oncotarget, 2019 - ncbi.nlm.nih.gov
Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor
with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance …

[HTML][HTML] RETRACTED ARTICLE: Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures

VN Ivanov, PW Grabham, CC Wu, TK Hei - Scientific reports, 2020 - nature.com
Radiotherapy combined with chemotherapy is the major treatment modality for human
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …

[HTML][HTML] Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

M Solinas, P Massi, V Cinquina, M Valenti… - PLoS …, 2013 - journals.plos.org
In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and
invasiveness in vitro and caused a decrease in the expression of a set of proteins …

Inhalant cannabidiol inhibits glioblastoma progression through regulation of tumor microenvironment

H Khodadadi, ÉL Salles, A Alptekin… - Cannabis and …, 2023 - liebertpub.com
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

KA Scott, AG Dalgleish, WM Liu - Molecular cancer therapeutics, 2014 - AACR
High-grade glioma is one of the most aggressive cancers in adult humans and long-term
survival rates are very low as standard treatments for glioma remain largely unsuccessful …

The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells

P Massi, A Vaccani, S Bianchessi, B Costa… - Cellular and Molecular …, 2006 - Springer
Recently, we have shown that the non-psychoactive cannabinoid compound cannabidiol
(CBD) induces apoptosis of glioma cells in vitro and tumor regression in vivo. The present …

[HTML][HTML] THC reduces ki67-immunoreactive cells derived from human primary glioblastoma in a GPR55-dependent manner

MR Kolbe, T Hohmann, U Hohmann, C Ghadban… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most frequent primary brain tumor entity with
poor prognosis and resistance to current standard therapies. Cannabinoids, such as …

[HTML][HTML] Cannabidiol induces apoptosis and perturbs mitochondrial function in human and canine glioma cells

C Gross, DA Ramirez, S McGrath… - Frontiers in …, 2021 - frontiersin.org
Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently
used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer …

Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models

L Soroceanu, E Singer, P Dighe… - Neuro-Oncology …, 2022 - academic.oup.com
Background Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile,
has been shown to produce antitumor activity across cancers in part through selective …