[HTML][HTML] Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The
challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of …
challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of …
[HTML][HTML] Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells
Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor
with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance …
with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance …
[HTML][HTML] RETRACTED ARTICLE: Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures
Radiotherapy combined with chemotherapy is the major treatment modality for human
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …
[HTML][HTML] Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
M Solinas, P Massi, V Cinquina, M Valenti… - PLoS …, 2013 - journals.plos.org
In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and
invasiveness in vitro and caused a decrease in the expression of a set of proteins …
invasiveness in vitro and caused a decrease in the expression of a set of proteins …
Inhalant cannabidiol inhibits glioblastoma progression through regulation of tumor microenvironment
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …
The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model
KA Scott, AG Dalgleish, WM Liu - Molecular cancer therapeutics, 2014 - AACR
High-grade glioma is one of the most aggressive cancers in adult humans and long-term
survival rates are very low as standard treatments for glioma remain largely unsuccessful …
survival rates are very low as standard treatments for glioma remain largely unsuccessful …
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
P Massi, A Vaccani, S Bianchessi, B Costa… - Cellular and Molecular …, 2006 - Springer
Recently, we have shown that the non-psychoactive cannabinoid compound cannabidiol
(CBD) induces apoptosis of glioma cells in vitro and tumor regression in vivo. The present …
(CBD) induces apoptosis of glioma cells in vitro and tumor regression in vivo. The present …
[HTML][HTML] THC reduces ki67-immunoreactive cells derived from human primary glioblastoma in a GPR55-dependent manner
MR Kolbe, T Hohmann, U Hohmann, C Ghadban… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most frequent primary brain tumor entity with
poor prognosis and resistance to current standard therapies. Cannabinoids, such as …
poor prognosis and resistance to current standard therapies. Cannabinoids, such as …
[HTML][HTML] Cannabidiol induces apoptosis and perturbs mitochondrial function in human and canine glioma cells
C Gross, DA Ramirez, S McGrath… - Frontiers in …, 2021 - frontiersin.org
Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently
used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer …
used both as a nutraceutical and therapeutic. Despite anecdotal evidence as an anticancer …
Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models
L Soroceanu, E Singer, P Dighe… - Neuro-Oncology …, 2022 - academic.oup.com
Background Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile,
has been shown to produce antitumor activity across cancers in part through selective …
has been shown to produce antitumor activity across cancers in part through selective …