[HTML][HTML] Cannabidiol affects extracellular vesicle release, miR21 and miR126, and reduces prohibitin protein in glioblastoma multiforme cells

US Kosgodage, P Uysal-Onganer, A MacLatchy… - Translational …, 2019 - Elsevier
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary
malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key …

[HTML][HTML] Cannabidiol induces cell cycle arrest and cell apoptosis in human gastric cancer SGC-7901 cells

X Zhang, Y Qin, Z Pan, M Li, X Liu, X Chen, G Qu… - Biomolecules, 2019 - mdpi.com
The main chemical component of cannabis, cannabidiol (CBD), has been shown to have
antitumor properties. The present study examined the in vitro effects of CBD on human …

[HTML][HTML] Anti-proliferative and cytotoxic effect of cannabidiol on human cancer cell lines in presence of serum

A Sainz-Cort, C Müller-Sánchez, E Espel - BMC research notes, 2020 - Springer
Objective Cannabinoids are able to reduce tumor growth in xenograft models, but their
therapeutic potential as anti-cancer drugs in humans is unclear yet. In vitro studies of the …

Cannabinoid signaling in glioma cells

A Ellert-Miklaszewska, IA Ciechomska, B Kaminska - Glioma Signaling, 2020 - Springer
Cannabinoids are a group of structurally heterogeneous but pharmacologically related
compounds, including plant-derived cannabinoids, synthetic substances and endogenous …

Δ9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells

G Galanti, T Fisher, I Kventsel, J Shoham… - Acta …, 2008 - Taylor & Francis
Background. The active components of Cannabis sativa L., Cannabinoids, traditionally used
in the field of cancer for alleviation of pain, nausea, wasting and improvement of well-being …

[HTML][HTML] Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

ÁC Murphy, B Weyhenmeyer, J Noonan, SM Kilbride… - Apoptosis, 2014 - Springer
Glioblastoma (GBM) is the most aggressive form of primary brain tumour, with dismal patient
outcome. Treatment failure is associated with intrinsic or acquired apoptosis resistance and …

[HTML][HTML] A low dose of pure cannabidiol is sufficient to stimulate the cytotoxic function of cik cells without exerting the downstream mediators in pancreatic cancer cells

F Garofano, A Sharma, H Abken… - International Journal of …, 2022 - mdpi.com
Despite numerous studies conducted over the past decade, the exact role of the
cannabinoid system in cancer development remains unclear. Though research has focused …

[HTML][HTML] Cannabidiol inhibits tumorigenesis in cisplatin-resistant non-small cell lung cancer via TRPV2

S Misri, K Kaul, S Mishra, M Charan, AK Verma… - Cancers, 2022 - mdpi.com
Simple Summary Drug resistance is the key factor contributing to the therapeutic failure of
lung cancer and the deaths related to lung cancer. Our study demonstrated that small …

Hypothesis: cannabinoid therapy for the treatment of gliomas?

G Velasco, I Galve-Roperh, C Sánchez, C Blázquez… - …, 2004 - Elsevier
Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most
frequent class of malignant primary brain tumours and one of the most aggressive forms of …

Effects on cell viability

M Guzman - Cannabinoids, 2005 - Springer
Cannabinoids are known to control the cell survival/death decision, leading to different
outcomes that depend on the nature of the target cell and its proliferative or differentiation …