The extracellular matrix (ECM) is an intricate network composed of an array of multidomain
macromolecules organized in a cell/tissue-specific manner. Components of the ECM link …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining
clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular …

The extracellular matrix (ECM) in the trabecular meshwork is believed to be essential for
maintenance of the normal outflow system. Excessive, abnormal accumulations of ECM …

The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

Glaucoma is an optic neuropathy affecting approximately 60 million people worldwide and is
the second most common cause of irreversible blindness. Elevated intraocular pressure …

Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling
the extracellular matrix (ECM) of the trabecular meshwork (TM). This entails sensing …

The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

Intraocular pressure (IOP) is the most critical risk factor for primary open angle glaucoma
(POAG). In most cases of POAG, IOP is increased because of an abnormally high aqueous …

Fibronectin fibrils are a major component of the extracellular matrix (ECM) of the trabecular
meshwork (TM). They are a key mediator of the formation of the ECM which controls …