Carbon monoxide (CO) is produced endogenously through the oxidative catabolism of
heme by heme oxygenase (HO). First described as a putative neuronal signaling …

Carbon monoxide (CO) is an endogenously derived gas formed from the breakdown of
heme by the enzyme heme oxygenase. Although long considered an insignificant and …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …

Carbon monoxide (CO) is an odorless, colorless and non-irritating gas. Even a small amount
of CO exposure is possibly associated with specific toxic effects. CO is also produced …

Over the last decade, studies have unraveled many aspects of endogenous production and
physiological functions of carbon monoxide (CO). The majority of endogenous CO is …

Small amounts of carbon monoxide (CO) are continuously produced in mammals. The
intracellular levels of CO can increase under stressful conditions following the induction of …

Carbon monoxide is produced endogenously in humans through the breakdown of
hemoglobin by heme oxygenase. Although originally thought to be a superfluous by-product …

Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has
been recently demonstrated to be an important endogenous molecule of gas that has …

Carbon monoxide (CO), hydrogen sulfide (H 2 S), and nitric oxide (NO) constitute
endogenous gaseous molecules produced by specific enzymes. These gases are …

Rationale: Vascular tissues produce carbon monoxide (CO) via HO-dependent and HO-
independent mechanisms; the former in tandem with biliverdin and iron and the latter as a …