WHAT IT IS ALREADY KNOW ABOUT THIS SUBJECT• Amiodarone is a highly effective
antiarrhythmic drug, but is limited in practice by its adverse effects, which are frequent on …

Objectives. We sought to assess the odds of experiencing adverse effects with low dose
amiodarone therapy compared with placebo. Background. An estimate of the likelihood of …

The distribution of the antiarrhythmic drug amiodarone and its principal lipophilic metabolite,
desethylamiodarone, was determined in postmortem tissues of six patients who received …

Amiodarone is a unique antiarrhythmic agent originally developed as a vasodilator.
Classified electrophysiologically as a Type III antiarrhythmic, it also has both nonspecific …

In 17 patients on long term therapy with amiodarone, serum drug levels measured by HPLC
were related to pharmacological effects. At steady state, serum levels were directly …

Amiodarone is an iodinated benzofuran derivative with recognised antiarrhythmic activity in
man. As yet, its pharmacokinetic behaviour has not been satisfactorily characterised …

Noncardiovascular adverse effects associated with amiodarone result in substantial
morbidity. Adverse effects involving the skin, liver, thyroid, and lungs have been reported in …

Synopsis Amiodarone, originally developed over 20 years ago, is a potent antiarrhythmic
drug with the actions of all antiarrhythmic drug classes. It has been successfully used in the …

The pharmacokinetic characteristics of amiodarone suggest extensive tissue deposition. We
confirmed this by measuring tissue concentrations of the drug and of its major metabolite …

This article attempts to provide an overview of the present knowledge of the
pharmacokinetics of amiodarone and how this relates to the clinical usage of oral …