A liquid chromatographic‐mass spectrometry (LC/MS) assay method was developed for the
determination of amiodarone and desethylamiodarone in rat specimens. Analytes were …

Five patients developed neurological adverse effects as they were treated with amiodarone
for 2 to 18 months. The daily maintenance dose did not exceed 400 mg. The neurological …

A simple high-performance liquid chromatographic method has been developed for the
measurement of the antiarrhythmic drug amiodarone in small (200 μl) volumes of plasma or …

Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding
whether to initiate or continue treatment with this medication. While mostly associated with …

A rapid and sensitive high-performance liquid chromatography (HPLC) method was
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …

In 23 patients treated with the iodine-containing antiarrhythmic drug amiodarone, the plasma
concentrations of amiodarone, desethylamiodarone and iodine have been studied. Besides …

Amiodarone is a potent and versatile antiarrhythmic. Despite side effects involving the lungs,
heart, thyroid, and other organs, it is effective in the treatment of refractory atrial and …

Clinical and laboratory features of 99 patients receiving long-term amiodarone therapy were
analyzed to determine which individuals may be at a high risk for developing amiodarone …

Objective Amiodarone is frequently associated with thyroid dysfunction. Identifying
predictors for amiodarone‐associated thyroid dysfunction and assessing treatment outcome …

Problems with pulmonary toxicity have emerged as a potentially limiting factor for
amiodarone use. We studied 24 consecutive patients receiving low-dose (ie,≤ 400 mg/day) …