5xFAD mice display sex-dependent inflammatory gene induction during the prodromal stage of Alzheimer's disease

Z Manji, A Rojas, W Wang… - Journal of …, 2019 - content.iospress.com
Alzheimer's disease (AD) pathology consists of extracellular deposits of amyloid-β peptides
(Aβ) and intracellular neurofibrillary tangles. These pathological alterations are …

Deficits in odor-guided behaviors in the transgenic 3xTg-AD female mouse model of Alzheimer׳ s disease

G Coronas-Sámano, W Portillo, VB Campos… - brain research, 2014 - Elsevier
Alzheimer׳ s disease (AD) is characterized by a number of alterations including those in
cognition and olfaction. An early symptom of AD is decreased olfactory ability, which may …

Cognitive and emotional profiles of aged Alzheimer's disease (3× TgAD) mice: effects of environmental enrichment and sexual dimorphism

G Blázquez, T Canete, A Tobena… - Behavioural brain …, 2014 - Elsevier
Alzheimer's disease is a neurodegenerative disorder associated with age which represents
the most common cause of dementia. It is characterized by an accelerated memory loss …

Impact of social relationships on Alzheimer's memory impairment: mechanistic studies

YH Hsiao, CH Chang, PW Gean - Journal of biomedical science, 2018 - Springer
Alzheimer's disease (AD) is characterized by progressive memory and neuronal loss
culminating in cognitive impairment that not only affects a person's living ability but also …

Early development of social deficits in APP and APP-PS1 mice

S Pietropaolo, P Delage, F Lebreton, WE Crusio… - Neurobiology of …, 2012 - Elsevier
Mimicking relevant behavioral features of the human pathology is one of the most important
challenges for animal models of neurological disorders including Alzheimer disease (AD) …

Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer's …

CH Poon, STN Wong, J Roy, Y Wang, HWH Chan… - Cells, 2023 - mdpi.com
A promising direction in the research on Alzheimer's Disease (AD) is the identification of
biomarkers that better inform the disease progression of AD. However, the performance of …

Sex‐biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi‐omic analysis

JL Bundy, C Vied, C Badger… - Journal of Comparative …, 2019 - Wiley Online Library
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
form of dementia. Like many neurological disorders, Alzheimer's disease has a sex‐biased …

Gene dosage dependent aggravation of the neurological phenotype in the 5XFAD mouse model of Alzheimer's disease

BC Richard, A Kurdakova, S Baches… - Journal of …, 2015 - content.iospress.com
In the present report, we extend previous findings in the 5XFAD mouse model with regard to
a characterization of behavioral deficits and neuropathological alterations. We demonstrate …

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease

V Landel, K Baranger, I Virard, B Loriod… - Molecular …, 2014 - Springer
Background The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining
momentum. Behavioral, electrophysiological and anatomical studies have identified age …

Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease

G Alexander, A Hanna, V Serna, L Younkin… - Behavioural brain …, 2011 - Elsevier
Behavioural and psychological signs and symptoms of dementia encompass a wide range
of neuropsychiatric disturbances which coincide with progressing cognitive decline in …