Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease

S Navakkode, JR Gaunt, MV Pavon, VA Bansal… - Aging …, 2021 - Wiley Online Library
Clinical studies have shown that female brains are more predisposed to neurodegenerative
diseases such as Alzheimer's disease (AD), but the cellular and molecular mechanisms …

The 5ŨFAD mouse model of Alzheimer's disease

C Ismeurt, P Giannoni, S Claeysen - Diagnosis and Management in …, 2020 - Elsevier
Since 2000, a plethora of transgenic mouse models have been developed to reproduce the
main features of Alzheimer's disease (AD). Due to the complexity of the disease, no ideal …

Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

O Ambrée, C Touma, N Görtz, K Keyvani, W Paulus… - Neurobiology of …, 2006 - Elsevier
Alzheimer's disease (AD) is not only characterized by cognitive decline and
neuropathological changes, but also by non-cognitive behavioral symptoms like …

Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

T Cassano, A Romano, T Macheda, R Colangeli… - Behavioural brain …, 2011 - Elsevier
Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of
Alzheimer's disease (3× Tg-AD). In the social transmission of food preference test, 3× Tg-AD …

Behavioral phenotyping of a murine model of Alzheimer's disease in a seminaturalistic environment using RFID tracking

L Lewejohann, AM Hoppmann, P Kegel… - Behavior research …, 2009 - Springer
Neurodegen erative disorders such as Alzheimer's disease (AD) are increasingly
threatening public health. Most animal models of AD consist of transgenic mice that are …

Cognitive trajectories in longitudinally trained 3xTg-AD mice

MR Duggan, Z Steinberg, T Peterson, TJ Francois… - Physiology & …, 2024 - Elsevier
Preclinical studies in Alzheimer's disease (AD) often rely on cognitively naïve animal models
in cross-sectional designs that can fail to reflect the cognitive exposures across the lifespan …

Genetic Mouse Models of Alzheimer′ s Disease

YS Mineur, D McLoughlin, WE Crusio… - Neural …, 2005 - Wiley Online Library
In the current minireview, we focus on genetic mouse models of Alzheimer′ s disease (AD).
Because various excellent, up‐to‐date reviews, special issues, and reliable websites are …

Updates on mouse models of Alzheimer's disease

MZ Zhong, T Peng, ML Duarte, M Wang… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

Cognitive and emotional alterations in young Alzheimer's disease (3xTgAD) mice: effects of neonatal handling stimulation and sexual dimorphism

T Cañete, G Blázquez, A Tobeña… - Behavioural brain …, 2015 - Elsevier
Alzheimer disease is the most common neurodegenerative disorder and cause of senile
dementia. It is characterized by an accelerated memory loss, and alterations of mood …

Age and gender differences for the behavioral phenotypes of 3xTg Alzheimer's disease mice

T Pairojana, S Phasuk, P Suresh, SP Huang… - Brain Research, 2021 - Elsevier
The triple transgenic Alzheimer's disease (3xTg-AD) strain is a common mouse model used
for studying the pathology and mechanism of Alzheimer's disease (AD). The 3xTg-AD strain …