Lung fibrotic responses to particle exposure

JC Bonner - Toxicologic pathology, 2007 - journals.sagepub.com
Particles generated from numerous anthropogenic sources have the potential to cause or
exacerbate lung diseases, including asthma, bronchitis, and COPD. Fibrotic reactions are a …

Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases

BT Mossman, PJ Borm, V Castranova, DL Costa… - Particle and Fibre …, 2007 - Springer
Background A symposium on the mechanisms of action of inhaled airborne particulate
matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials …

Antioxidant defense mechanisms and the toxicity of fibrous and nonfibrous particles

KE Driscoll, JM Carter, PJA Borm - Inhalation toxicology, 2002 - Taylor & Francis
A topic that continues to attract considerable interest in many areas of biomedical research,
is that of the cell's defense against oxidative stress. Various mechanisms exist to protect …

[HTML][HTML] The significance of nanoparticles in particle-induced pulmonary fibrosis

JD Byrne, JA Baugh - McGill Journal of Medicine: MJM, 2008 - ncbi.nlm.nih.gov
Exposure to airborne nanoparticles contributes to many chronic pulmonary diseases.
Nanoparticles, classified as anthropogenic and natural particles, and fibers of diameters less …

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

HM Braakhuis, MVDZ Park, I Gosens… - Particle and fibre …, 2014 - Springer
The increasing manufacture and use of products based on nanotechnology raises concerns
for both workers and consumers. Various studies report induction of pulmonary inflammation …

Particle-mediated extracellular oxidative stress in the lung

FJ Kelly, IS Mudway, EK Donaldson… - Particle Toxicology, 2007 - books.google.com
During the last decade, concerns have increased within both political and scientific
communities over the impact of airborne particulate matter (PM) on public health. This …

Airborne particles evoke an inflammatory response in human airway epithelium. Activation of transcription factors

A Baeza-Squiban, V Bonvallot, S Boland… - Cell biology and …, 1999 - Springer
PM10, the commonly used indicator of respirable environmental suspended particulate
matter with a mean aerodynamic diameter of less than 10 μm, is composed of organic or …

Ultrafine (nanometre) particle mediated lung injury

K Donaldson, XY Li, W MacNee - Journal of aerosol science, 1998 - Elsevier
Experimental studies have shown that rats exposed to ultrafine particles of, for example,
titanium dioxide or carbon black, sustain more lung injury and pathology than rats exposed …

Can in vitro assays substitute for in vivo studies in assessing the pulmonary hazards of fine and nanoscale materials?

CM Sayes, KL Reed, S Subramoney, L Abrams… - Journal of Nanoparticle …, 2009 - Springer
Risk evaluations for nanomaterials require the generation of hazard data as well as
exposure assessments. Most of the validated nanotoxicity studies have been conducted …

A short history of the toxicology of inhaled particles

K Donaldson, A Seaton - Particle and fibre toxicology, 2012 - Springer
Particle toxicology arose in order to understand the mechanisms of adverse effects of 3
major particle types that had historically exerted the greatest toll of ill-health—quartz, coal …