Background Parkinson's disease is a common neurodegenerative problem. Pramipexole
(PPX) plays protective role in Parkinson's disease. Nevertheless, the mechanism of PPX in …

Pramipexole (PPX) is a common drug for the treatment of Parkinson's disease. However, the
mechanism allows PPX in the progression of Parkinson's disease remains largely unknown …

The progression of Parkinson's disease (PD) is often accompanied by the loss of substantia
nigra dopaminergic neurons, mitophagy damage, learning, and memory impairment …

Inflammation is one of the pathogenic processes in Parkinson's disease (PD). Dopamine
receptor agonist pramipexole (PPX) is extensively used for PD treatment in clinics. A number …

A major hallmark of Parkinson's disease (PD) is the degeneration of dopaminergic neurons
in the substantia nigra, and the causative mechanism is thought to be the activation of …

Parkinson's disease (PD) is a common neurodegenerative disease with global health and
economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction …

P arkinson's disease (PD) is the most prevalent movement disorder characterized by
selective loss of midbrain dopaminergic (DA) neurons. MicroRNA‐124 (mi R‐124) is …

Objectives: miR-199a can regulate autophagy, its underlying mechanisms remain unknown.
The purpose of this study was to investigate the mechanisms of miR-199a involved in …

Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in
Parkinson's disease, but the regulatory mechanism remains elusive. Prohibitin-2 (PHB2) is a …

We have previously demonstrated the unexpected neuroprotection of the anti-cancer agent
SU4312 in cellular models associated with Parkinson's disease (PD). However, the precise …