NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains
enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted …

Chronic inflammation in tumor microenvironment plays an important role at different stages
of tumor development. The specific mechanisms of the association and its role in providing a …

NLRX1, the mitochondrial NOD-like receptor (NLR), modulates apoptosis in response to
both intrinsic and extrinsic cues. Insights into the mechanism of how NLRX1 influences …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal
tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

An increased level of proinflammatory cytokines, including TNF-α in tumor microenvironment
regulates the bioenergetic capacity, immune evasion and survival of cancer cells. Emerging …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

Background Regulation of cell death during neurodegeneration is one of the key factors that
play a role in the speed at which a disease progresses. Out of several cellular pathways …