Mitochondrial dysfunction has long been implicated to have a causative role in organismal
aging. A mitochondrial molecule, nucleotide‐binding domain and leucine‐rich‐repeat …

The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

To subvert host immunity, influenza A virus (IAV) induces early apoptosis in innate immune
cells by disrupting mitochondria membrane potential via its polymerase basic protein 1 …

Several metabolic, cardiovascular, and neurological disorders are characterized by
mitochondrial dysfunction followed by dysregulation of cellular energetics. Mitochondria play …

Apoptosis or programmed cell death is an extremely coordinated phenomenon that involves
the participation of a complex interacting crosstalk between the endoplasmic reticulum and …

The NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome has been
implicated in renal inflammation and fibrosis. However, the biological function of …

Abstract NOD-like receptor (NLR) X1 (NLRX1) is an ubiquitously expressed inflammasome-
independent NLR that is uniquely localized in mitochondria with as yet unknown effects on …

Noxa is a Bcl-2 homology domain-containing pro-apoptotic mitochondrial protein. Noxa
mRNA and protein expression are upregulated by dsRNA or virus, and ectopic Noxa …

Nod-like receptor (NLR) X1 is an NLR family protein that localizes to the mitochondrial
matrix and modulates reactive oxygen species production, possibly by directly interacting …

Mitochondrial outer membrane permeabilization and cytochrome c release promote
caspase activation and execution of apoptosis through cleavage of specific caspase …