Mutations in leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and
sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple …

The coordinated communication between the mitochondria and nucleus is essential for
cellular activities. Nonetheless, the pathways involved in this crosstalk are scarcely …

Retinoid X receptor (RXR) plays a central role in the regulation of intracellular receptor
signaling pathways by acting as a ubiquitous heterodimerization partner of many nuclear …

Lon now emerges as a major regulator of multiple mitochondrial functions in human beings.
Lon catalyzes the degradation of oxidatively modified matrix proteins, chaperones the …

To identify human proteins that bind to the Smac and caspase-9 binding pocket on the
baculoviral inhibitor of apoptosis protein (IAP) repeat 3 (BIR3) domain of human XIAP, we …

Background Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye
disease due to mutations in mitochondrial DNA. However, there is no effective treatment for …

Mitochondria have been classically characterized as organelles with responsibility for
cellular energy production in the form of ATP, but they are also the organelles through which …

Human Lon protease is a mitochondrial matrix protein with several functions, including
protein degradation, mitochondrial DNA (mtDNA) binding, and chaperone activity. Lon is …

ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have
been implicated in TNFα (tumour necrosis factor α)-mediated signalling. In the present study …

Mitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little
literature has been undertaken into detailed investigations on how Lon regulates apoptosis …