The mitochondrial matrix protease LONP1 is an essential part of the organellar protein
quality control system. LONP1 has been shown to be involved in respiration control and …

Bcl-2 and Bcl-x L serve as critical inhibitors of apoptosis triggered by a broad range of
stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) …

The 1246 cell line is a C3H mouse teratoma-derived adipogenic cell line that can proliferate
and differentiate in defined medium. We have constructed a recombinant phage library …

Most cell death stimuli trigger the mitochondrial release of cytochrome c and other cofactors
that induce caspase activation and ensuing apoptosis. Apoptosis is also associated with …

Background The NLRP3 inflammasome is a sensor of specific pathogen, host and
environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves …

Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal
vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in …

Once thought to be a random process of cell death, necrosis can proceed via a defined
molecular mechanism and is integral to physiological and pathological states. In particular a …

Inflammasomes are multimeric protein complexes that induce the cleavage and release of
bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse …

Signaling diversity and subsequent complexity in higher eukaryotes is partially explained by
one gene encoding a polypeptide with multiple biochemical functions in different cellular …

A detailed understanding of the signaling pathways by which c-Myc elicits apoptosis has
proven elusive. In the current study, we have evaluated whether the activation of the …