We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated
by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β) …

The nuclear respiratory factor-1 (NRF1) gene is activated by lipopolysaccharide (LPS),
which might reflect TLR4-mediated mitigation of cellular inflammatory damage via initiation …

The mitochondrial matrix GTPase NOA1 is a nuclear encoded protein, essential for
mitochondrial protein synthesis, oxidative phosphorylation and ATP production. Here, we …

It is now well established that the mitochondrion is a central regulator of mammalian cell
apoptosis. However, the importance of this organelle in non-mammalian apoptosis has long …

Reactive oxygen species (ROS) may cause cellular damage and oxidative stress-induced
cell death. Autophagy, an evolutionarily conserved intracellular catabolic process, is …

Cells subjected to environmental stresses undergo regulated cell death (RCD) when
homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive …

Excess production of reactive oxygen species (ROS) is known to cause apoptotic cell death.
However, the molecular mechanisms whereby ROS induce apoptosis remain elusive. Here …

In recent years major progress has been made in understanding the molecular steps of
death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-κB-mediated …

The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6
is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal …

Protein kinase-B (PKB) and its target, the forkhead transcription factor like 1
(FKHRL1)/FoxO3a, have been suggested as regulators of neurotrophin-mediated cell …