Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …

Amyloid plaques, derived from aggregates of amyloid β (Aβ), are closely linked to the
pathogenesis of Alzheimer's disease (AD). Another neuropathological hallmark is the loss of …

Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of
nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's …

We have recently reported evidence that a very high affinity interaction between the β‐
amyloid peptide Aβ1‐42 and the α7 nicotinic acetylcholine receptor (α7nAChR) may be a …

Alzheimer's disease, a neurodegenerative disorder, is characterized by accumulation of
amyloid beta (Aβ) plaques, neurofibrillary tangles and loss of cholinergic neurons. The …

Amyloid-β (Aβ) peptides in the brain of patients with Alzheimer's disease (AD) assemble into
various aggregation forms that differ in size, structure, and functional properties. Previous …

Elevated amyloid-β peptide (Aβ) and loss of nicotinic acetylcholine receptors (nAChRs)
stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery of an Aβ …

It has been recently shown that the Alzheimer's disease (AD) pathogenic peptide amyloid β1–
42 (Aβ1–42) binds to the α7 nicotinic acetylcholine receptor (α7nAChR) with high affinity …

Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the
loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events …

Alzheimer's disease produces a devastating decline in mental function, with profound effects
on learning and memory. Early consequences of the disease include the specific loss of …