Background: Cytotoxic T-lymphocytes (CTLs) recognize complexes of short peptides with
major histocompatibility complex (MHC) class I molecules. MHC molecules are polymorphic …

Poly-N-acylated amines, as a new class of synthetic non-peptide ligands for the murine
major histocompatibility complex (MHC) class I molecule H-2K b, were developed on the …

The ability of MHC molecules to present a broad spectrum of peptide antigens for T cell
recognition requires a compromise between high affinity and broad specificity. Three …

Recent developments have led to a clearer understanding of the association between
peptides and MHC molecules. It is now clear that the peptides presented by MHC class I or …

Proteins are composed of α-amino acid residues. This consistency in backbone structure
likely serves an important role in the display of an enormous diversity of peptides by class II …

T-cell-specific immunity functions in a major histocompatibility complex (MHC)-dependent
manner. MHC molecules present antigenic peptides on the surface of cells to be recognised …

Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant
epitopic peptides to T cell receptors (TCRs), which employ interactions between …

Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide
fragments on the surface of antigen presenting cells (APCs) to T‑cell receptors. Recognition …

The peptides that bind class I MHC molecules are restricted in length and often contain key
amino acids, anchor residues, at particular positions. The side-chains of peptide anchor …

Major histocompatibility complex (MHC) molecules are a key element of the cellular immune
response. Encoded by the MHC they are a family of highly polymorphic peptide receptors …