Knowledge on mechanisms involved in early prediction of response to antidepressant
medication may help optimize clinical decision making. Recent studies regarding response …

Antidepressants must be taken for weeks before response can be assessed with many
patients not responding to the first medication prescribed. This often results in long delays …

The goal of this study was to evaluate the relationship between early change in
psychosocial function independent of depression severity and longer-term symptomatic …

Background In subjects with depression, exposure to antidepressants improves recognition
of positive emotions. This phenomenon, which occurs early in the course of treatment, has …

BACKGROUND: Delayed onset of efficacy of antidepressants and a high proportion of
depressed patients being poor or non-responders to antidepressants are well known clinical …

Early improvement of depressive symptoms during the first two weeks of antidepressant
treatment has been discussed to be a resilience signal predicting a later positive treatment …

Current antidepressant agents are similar in efficacy to the original drugs discovered in the
1950s. The development of new treatments for depression is, however, limited by the …

Background Despite the widespread use of antidepressants in clinical practice, the current
trial-and-error approach to medication selection contributes to treatment failure and …

Objectives. Although the treatment of depressive illness aims to restore the imbalance
between an excess of negative affect (NA) and a shortage of positive affect (PA), no study …

BackgroundImprovement in depression within the first 2 weeks of antidepressant treatment
predicts good outcomes, but non-improvers can still respond or remit, whereas improvers …