Objective: While there is some indication from studies in the acute phase of antidepressant
treatment that there are differences in the timing of improvement in symptoms, relatively little …

The cardinal symptoms of major depressive disorder (MDD) are heightened depressed
mood (negative affectivity, or NA) and diminished interest or pleasure (positive affectivity, or …

There is preliminary evidence that dysphoric symptoms are associated with maladaptive
regulation of positive emotion. We investigated to what extent this pattern is unique to …

Although the cost of poor treatment outcomes of depression is staggering, we do not yet
have clinically useful methods for selecting the most effective antidepressant for each …

Abstract Patients with Major Depressive Disorder (MDD) and no improvement after two
weeks of antidepressant pharmacotherapy have a high risk of treatment failure. The aim of …

Background We have previously shown that single doses of serotonin-selective and
noradrenaline-selective antidepressant agents produce positive biases in measures of …

In the treatment of depression, there is considerable interest in the time course of response
and, in particular, the speed with which individuals recover from depressive episodes …

Antidepressant discontinuation increases the risk of experiencing depressive symptoms. In a
repeated single-subject design, we tested whether transitions in depression were preceded …

Background Identification of biomarkers predicting therapeutic outcome of antidepressant
treatment is one of the most important tasks in current research because it may transform the …

Abstract Objective To use the Clinical Global Impression‐Severity (CGI‐S) scale to estimate
clinically meaningful and clinically substantial changes as measured using the Montgomery …