A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation
Summary The coronavirus disease 2019 (COVID-19) pandemic underscores the need to
better understand animal-to-human transmission of coronaviruses and adaptive evolution …
better understand animal-to-human transmission of coronaviruses and adaptive evolution …
Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous …
[HTML][HTML] SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility
During the evolution of SARS-CoV-2 in humans a D614G substitution in the spike (S) protein
emerged and became the predominant circulating variant (S-614G) of the COVID-19 …
emerged and became the predominant circulating variant (S-614G) of the COVID-19 …
SARS-CoV-2 spike D614G change enhances replication and transmission
During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike
glycoprotein (S) has emerged; virus containing this substitution has become the …
glycoprotein (S) has emerged; virus containing this substitution has become the …
Rapid and parallel adaptive mutations in spike S1 drive clade success in SARS-CoV-2
KE Kistler, J Huddleston, T Bedford - Cell Host & Microbe, 2022 - cell.com
The SARS-CoV-2 pandemic has resulted in numerous virus variants, some of which have
altered receptor-binding or antigenic phenotypes. Here, we quantify the degree to which …
altered receptor-binding or antigenic phenotypes. Here, we quantify the degree to which …
Analysis of spike protein variants evolved in a novel in vivo long-term replication model for SARS-CoV-2
D Kim, J Kim, M Kim, H Park, S Park… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The spectrum of SARS-CoV-2 mutations have increased over time, resulting in
the emergence of several variants of concern. Persistent infection is assumed to be involved …
the emergence of several variants of concern. Persistent infection is assumed to be involved …
[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …
[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …
The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types
Recently, a novel isolate of the SARS-CoV-2 virus carrying a point mutation in the Spike
protein (D614G) has emerged and rapidly surpassed others in prevalence, including the …
protein (D614G) has emerged and rapidly surpassed others in prevalence, including the …
Perspectives: SARS-CoV-2 spike convergent evolution as a guide to explore adaptive advantage
Viruses rapidly co-evolve with their hosts. The 9 million sequenced SARS-CoV-2 genomes
by March 2022 provide a detailed account of viral evolution, showing that all amino acids …
by March 2022 provide a detailed account of viral evolution, showing that all amino acids …
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