With a constant focus on the primary tumor, the current approaches in drug development in
oncology yield dismal results. However over 90 percent of cancer deaths today are due to …

The suppression of cancer metastasis is an urgent therapeutic need. Yet, most existing
drugs inhibit only cancer cell proliferation. Historically, the reason is the much later …

While combinational diagnostic and treatment strategies over the past decades have
significantly improved the overall survival of cancer patients, metastatic cancer remains a …

Anti-cancer targeting drugs appear to be a new and powerful" weapon" for cancer therapies.
These targeting drugs are directed against specific molecules that are over-expressed or …

Neoplasm metastasis is a multiple-step and multi-level feature that is resistance to current
norm of anticancer drugs. More seriously, current anticancer drugs are commonly derived …

Most cancer-related deaths are a result of metastasis, and thus the importance of this
process as a target of therapy cannot be understated. By asking 'how can we effectively treat …

Cancer chemotherapy, usually as a combination of different drugs or as an adjuvant to
surgery or radiotherapy, has been successful in the treatment of some of the rarer cancers …

Molecular mechanisms and clinical use of targeted anticancer drugs Page 1 126 VOLUME 36 :
NUMBER 4 : AUGUST 2013 ARTICLE Full text free online at www.australianprescriber.com …

Since the introduction of a policy by the International Committee of Medical Journal Editors
(ICMJE) requiring that interventional clinical trials are registered in a public trial registry at …

Metastatic disease is responsible for 90% of death from solid tumors. However, only a
minority of metastasis-specific targets has been exploited therapeutically, and effective …