The design of a subunit vaccine against the malaria parasite relies on the epitopes
recognized by T cells being identified and polymorphisms therein being defined. Here we …

The definition of human T-cell antigenic sites is important for subunit vaccine development of
a peptide immunogen if the goal is to allow antibody boosting during infection or to stimulate …

Identification of T cell antigenic sites is critical for antisporozoite malarial vaccine design.
Here, we present data that define two minimal functional T cell sites present in an …

Variation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium
falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using …

Genetic analysis of field isolates of Plasmodium falciparum has shown selective
accumulation of point mutations within the immunologically sensitive sites of the …

To determine the nature and extent of variation in the T cell sites of the Plasmodium
falciparum circumsporozoite (CS) protein, a candidate antigen in the development of a …

The circumsporozoite (CS) protein that covers the surface of infectious sporozoites is a
candidate antigen in malaria vaccine development. To determine the extent of B-and T …

Sequence polymorphism has been reported for virtually all malaria antigens and, in the case
of the circumsporozoite (CS) protein, this variation is in the form of point mutations …

In order to characterize T cell epitopes in the Plasmodium falciparum circumsporozoite (CS)
protein sequence, we isolated T cell clones, from non‐immune donors, which reacted with …

The malaria vaccine candidate RTS, S/AS01 is based on immunogenic regions of
Plasmodium falciparum circumsporozoite protein (CSP) from the 3D7 reference strain and …