[PDF][PDF] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

J Schmitz, A Owyang, E Oldham, Y Song, E Murphy… - Immunity, 2005 - cell.com
Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important
functions in host defense, immune regulation, and inflammation. Insight into their biological …

[HTML][HTML] Role of the IL-33-ST2 axis in sepsis

H Xu, HR Turnquist, R Hoffman, TR Billiar - Military Medical Research, 2017 - Springer
Sepsis remains a major clinical problem with high morbidity and mortality. As new
inflammatory mediators are characterized, it is important to understand their roles in sepsis …

IL-33 and IL-33 receptors in host defense and diseases

K Oboki, T Ohno, N Kajiwara, H Saito… - Allergology …, 2010 - jstage.jst.go.jp
ABSTRACT Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-
1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated …

[HTML][HTML] IL33: roles in allergic inflammation and therapeutic perspectives

BCL Chan, CWK Lam, LS Tam, CK Wong - Frontiers in immunology, 2019 - frontiersin.org
Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …

[HTML][HTML] Interleukin-33 in malignancies: friends or foes?

JX Shen, J Liu, GJ Zhang - Frontiers in immunology, 2018 - frontiersin.org
The human Interleukin-33 (IL-33), a member of the IL-1 family, is the cytokine as a cell
endogenous alarmin, released by damaged or necrotic barrier cells (endothelial and …

[HTML][HTML] IL-33 biology in cancer: An update and future perspectives

WJ Yeoh, VP Vu, P Krebs - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively
expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress …

[HTML][HTML] IL-33 in rheumatic diseases

Y Dong, J Zhong, L Dong - Frontiers in Medicine, 2021 - frontiersin.org
Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial
cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain …

IL-33 is a crucial amplifier of innate rather than acquired immunity

K Oboki, T Ohno, N Kajiwara, K Arae… - Proceedings of the …, 2010 - National Acad Sciences
IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that
is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been …

[HTML][HTML] Role of IL-33 in inflammation and disease

AM Miller - Journal of inflammation, 2011 - Springer
Abstract Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is
expressed by mainly stromal cells, such as epithelial and endothelial cells, and its …

Cellular context of IL-33 expression dictates impact on anti-helminth immunity

LY Hung, Y Tanaka, K Herbine, C Pastore… - Science …, 2020 - science.org
Interleukin-33 (IL-33) is a pleiotropic cytokine that can promote type 2 inflammation but also
drives immunoregulation through Foxp3+ Treg expansion. How IL-33 is exported from cells …