We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …

Myocardial dysfunction and heart failure perturb cardio-vascular homeostatic signaling
pathways as well as initiate a program of molecular, biochemical, and structural …

BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …

Xanthine oxidase (XO) activity contributes to both abnormal excitation-contraction (EC)
coupling and cardiac remodeling in heart failure (HF). β-Adrenergic hyporesponsiveness …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …

Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …

We investigated whether xanthine oxidase inhibition with febuxostat enhances left
ventricular (LV) function and improves myocardial high energy phosphates (HEP) in dogs …