Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure
LC Amado, AP Saliaris, SVY Raju, S Lehrke… - Journal of molecular and …, 2005 - Elsevier
We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …
on both ventricular and vascular performance in evolving heart failure (HF), thereby …
Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction?
RJ Hajjar, JA Leopold - Circulation research, 2006 - Am Heart Assoc
Myocardial dysfunction and heart failure perturb cardio-vascular homeostatic signaling
pathways as well as initiate a program of molecular, biochemical, and structural …
pathways as well as initiate a program of molecular, biochemical, and structural …
Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters
K Hayashi, H Kimata, K Obata, A Matsushita… - Journal of cardiac …, 2008 - Elsevier
BACKGROUND: Oxidative stress is implicated in cardiac remodeling and failure. We tested
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …
whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and …
Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart
WF Saavedra, N Paolocci, ME St. John… - Circulation …, 2002 - Am Heart Assoc
Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …
Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and β-adrenergic hyporesponsiveness in heart failure
AP Saliaris, LC Amado, KM Minhas… - American Journal …, 2007 - journals.physiology.org
Xanthine oxidase (XO) activity contributes to both abnormal excitation-contraction (EC)
coupling and cardiac remodeling in heart failure (HF). β-Adrenergic hyporesponsiveness …
coupling and cardiac remodeling in heart failure (HF). β-Adrenergic hyporesponsiveness …
Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment
L Zhao, BM Roche, JL Wessale, A Kijtawornrat, JL Lolly… - Life Sciences, 2008 - Elsevier
Xanthine oxidase (XO) expression is increased in the failing heart, and animal studies in
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …
rodents and dogs showed that XO inhibition with allopurinol can improve left ventricular (LV) …
Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload
JD Gladden, BR Zelickson… - American Journal …, 2013 - journals.physiology.org
Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …
Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy
KM Minhas, RM Saraiva, KH Schuleri, S Lehrke… - Circulation …, 2006 - Am Heart Assoc
Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …
Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure
T Ukai, CP Cheng, H Tachibana, A Igawa, ZS Zhang… - Circulation, 2001 - Am Heart Assoc
Background—Superoxide (O2−) generated by enhanced xanthine oxidase (XO) activity may
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …
contribute to the increased myocardial oxidative stress in heart failure (CHF). Because …
Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure
We investigated whether xanthine oxidase inhibition with febuxostat enhances left
ventricular (LV) function and improves myocardial high energy phosphates (HEP) in dogs …
ventricular (LV) function and improves myocardial high energy phosphates (HEP) in dogs …