OBJECTIVES We administered antioxidant vitamins to rabbits with pacing-induced
cardiomyopathy to assess whether antioxidant therapy retards the progression of congestive …

Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance
in heart failure? - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

The syndrome of congestive heart failure (HF) is the most important cardiovascular disorder
in the Western world from public health and health care resource utilization perspectives. 1 …

Aims: Oxidative stress and fibrosis is implicated in cardiac remodeling and failure. We tested
whether allopurinol could decrease myocardial oxidative stress and attenuate cardiac …

ABSTRACT Background and Aim: Increased xanthine oxidase (XO) activity may contribute
to heart failure pathophysiology. This study evaluated whether a XO inhibitor, allopurinol …

The role of angiotensin II and reactive oxygen species in the exacerbation of diastolic heart
failure is unknown. We examined the therapeutic effect of angiotensin blockade on …

Background—Hyperuricemia is common in chronic heart failure (CHF), and it is a strong
independent marker of prognosis. Upregulated xanthine oxidase (XO) activity and impaired …

Oxidative stress plays a central role in the pathogenesis of heart failure. We aimed to
determine whether the antioxidant N‐acetylcysteine can attenuate cardiac fibrosis and …

Background It has long been suggested that reactive oxygen species (ROS) play a role in
oxygen sensing via peripheral chemoreceptors, which would imply their involvement in …

Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …