Allopurinol as an effective inhibitor of the enzyme xanthine oxidase (XO) has been used for
several decades for the treatment of patients with gout and hyperuricemia. Because the …

Oxidative stress plays a central role in the pathogenesis of heart failure. We aimed to
determine whether the antioxidant N‐acetylcysteine can attenuate cardiac fibrosis and …

Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are
seen in patients who have worse ventricular function, functional capacity, and prognosis …

Clinical heart failure has been defined for a long time as a clinical syndrome with symptoms
and signs including shortness of breath, cyanosis, ascites, and edema. However, in recent …

Accumulating evidence suggests that high serum uric acid (UA) is associated with left
ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory …

Uric acid (UA) is the end product of purine metabolism in humans. Hyperuricemia is often
found in patients with chronic heart failure (CHF). The increase of serum UA level is …

Background—Congestive heart failure (CHF) is a disease that is characterized by
progressive left ventricular (LV) dysfunction and dilatation. Oxidative stress is thought to …

Background—Increased oxidative stress in chronic heart failure is thought to contribute to
endothelial dysfunction. Xanthine oxidase produces oxidative stress and therefore we …

Background There are several mechanisms, including inflammation, oxidative stress and
abnormal calcium homeostasis, involved in the pathogenesis of atrial fibrillation. In diabetes …

Objective It has been suggested that reduction in glucose levels contributes to the
prolongation of life span of rodents in conjunction with restricted food intake, and …