Introduction The T allele of a single nucleotide polymorphism (SNP: rs2544390) in
lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk …

Gout, a multifactorial disease characterized by acute inflammatory arthritis, is caused as a
consequence of hyperuricemia. Previous genetic studies have revealed that gout and serum …

Gout is usually characterized by uric acid-induced recurrent attacks of acute inflammatory
arthritis. CC chemokine ligand 2 (CCL2), a chemokine involved in the recruitment and …

This study aimed to identify functional associations of cis-regulatory regions with gout
susceptibility using data resulted from a genome-wide association study (GWAS), and to …

Background Gout progresses through three stages: hyperuricemia, deposition of
monosodium urate (MSU) crystals, and innate immune system response to MSU crystals …

The effects of genetic variants on the interaction between hyperlipidemia and sex have not
been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National …

Objective. To validate the association between genetic polymorphisms and gout in
Japanese patients, and to investigate the cumulative effects of multiple genetic factors on the …

In this study, we analyzed single nucleotide polymorphisms (SNP) in urate transporter genes
to examine the pathogenesis of gout. We conducted a 1: 1-matched case-control study that …

Objective To determine chromosomal localization of the primary gout susceptibility gene in a
pedigree. Methods The clinical data and the peripheral blood samples were collected in the …

Interventions: Six direct descendants and 3 healthy spouses in 1 family were recruited in our
study. Whole-exome sequencing was conducted in all participants. Outcomes: Whole …