[HTML][HTML] AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2
BN Fahy, M Schlieman, S Virudachalam… - British journal of …, 2003 - nature.com
Activation of the serine/threonine kinase AKT is common in pancreatic cancer; inhibition of
which sensitises cells to the apoptotic effect of chemotherapy. Of the various downstream …
which sensitises cells to the apoptotic effect of chemotherapy. Of the various downstream …
The role of Akt activation in the response to chemotherapy in pancreatic cancer
CM Parsons, D Muilenburg, TL Bowles… - Anticancer …, 2010 - ar.iiarjournals.org
The PI3K/Akt signaling pathway is constitutively activated in some pancreatic cancers; when
activated, it inhibits chemotherapy-mediated apoptosis. We examined whether Akt activity …
activated, it inhibits chemotherapy-mediated apoptosis. We examined whether Akt activity …
[HTML][HTML] Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells
S Hövelmann, TL Beckers, M Schmidt - British journal of cancer, 2004 - nature.com
Protein kinase B/Akt has been described as a central mediator of antiapoptotic signals in
cancer cells. Furthermore, Akt has been shown to affect cell cycle progression and …
cancer cells. Furthermore, Akt has been shown to affect cell cycle progression and …
[HTML][HTML] Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
MG Schlieman, BN Fahy, R Ramsamooj… - British journal of …, 2003 - nature.com
When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal
implicated in chemoresistance of various cancers. The mechanism (s) of AKT activation are …
implicated in chemoresistance of various cancers. The mechanism (s) of AKT activation are …
Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.
C Page, HJ Lin, Y Jin, VP Castle, G Nunez… - Anticancer …, 2000 - europepmc.org
The AKT oncogenes are amplified or AKT kinase activity is constitutively elevated in several
types of human malignancy. We sought to determine whether AKT might play a role in the …
types of human malignancy. We sought to determine whether AKT might play a role in the …
Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status
F Buontempo, T Ersahin, S Missiroli, S Senturk… - Investigational new …, 2011 - Springer
The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is involved in cell survival and anti-apoptotic signaling. Akt has been shown to be …
(PI3K), is involved in cell survival and anti-apoptotic signaling. Akt has been shown to be …
[HTML][HTML] Akt as a target for cancer therapy: more is not always better (lessons from studies in mice)
Abstract The PI3K/Akt signalling pathway is one of the most frequently altered signalling
networks in human cancers and has become an attractive target in anticancer therapy …
networks in human cancers and has become an attractive target in anticancer therapy …
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
D DeFeo-Jones, SF Barnett, S Fu, PJ Hancock… - Molecular cancer …, 2005 - AACR
Recent studies indicate that dysregulation of the Akt/PKB family of serine/threonine kinases
is a prominent feature of many human cancers. The Akt/PKB family is composed of three …
is a prominent feature of many human cancers. The Akt/PKB family is composed of three …
AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
S Koseoglu, Z Lu, C Kumar, P Kirschmeier… - Cancer biology & …, 2007 - Taylor & Francis
AKT is a key serine/threonine kinase in the PTEN/PI3K/AKT pathway1 and activation of AKT
is often observed in human cancers. To explore the role of AKT in cell survival in different …
is often observed in human cancers. To explore the role of AKT in cell survival in different …
Inhibition of AKT abrogates chemotherapy-induced NF-κB survival mechanisms: implications for therapy in pancreatic cancer1
BN Fahy, MG Schlieman… - Journal of the …, 2004 - journals.lww.com
Background When activated, the nuclear factor (NF)-κB pathway is a potent cellular signal
that inhibits apoptotic cell death. Pancreatic cancer is resistant to the apoptotic effect of …
that inhibits apoptotic cell death. Pancreatic cancer is resistant to the apoptotic effect of …