Cystic fibrosis: a polymicrobial infectious disease

CD Sibley, H Rabin, MG Surette - Future microbiology, 2006 - Taylor & Francis
Cystic fibrosis (CF) is the most common lethal genetic disease in the Caucasian population,
and should be considered an infectious disease because of the basic pathophysiology …

The polymicrobial nature of airway infections in cystic fibrosis: Cangene Gold Medal Lecture

CD Sibley, MG Surette - Canadian journal of microbiology, 2011 - cdnsciencepub.com
Microbial communities characterize the airways of cystic fibrosis (CF) patients. Members of
these diverse and dynamic communities can be thought of as pathogens, benign …

The cystic fibrosis lung microbiome

MG Surette - Annals of the American Thoracic Society, 2014 - atsjournals.org
The chronic colonization of the lower airways by bacterial pathogens is the leading cause of
morbidity and mortality in patients with cystic fibrosis (CF). Pseudomonas aeruginosa is the …

The cystic fibrosis airway microbiome

HR Rabin, MG Surette - Current opinion in pulmonary medicine, 2012 - journals.lww.com
A comprehensive understanding of airway infections offers the potential for improved
disease management in CF patients. Accurate quantitative microbiology will be a …

[HTML][HTML] Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis

MD Parkins, RA Floto - Journal of Cystic Fibrosis, 2015 - Elsevier
Chronic suppurative lower airway infection is a hallmark feature of cystic fibrosis (CF).
Decades of experience in clinical microbiology have enabled the development of improved …

Microbiology of cystic fibrosis airway disease

AC Blanchard, VJ Waters - Seminars in respiratory and critical …, 2019 - thieme-connect.com
Although survival of individuals with cystic fibrosis (CF) has been continuously improving for
the past 40 years, respiratory failure secondary to recurrent pulmonary infections remains …

Cystic fibrosis lung infections: polymicrobial, complex, and hard to treat

LM Filkins, GA O'Toole - PLoS pathogens, 2015 - journals.plos.org
Historically, H. influenzae and S. aureus were considered to be the primary organisms
infecting the airways of infants and children with CF, followed by P. aeruginosa or …

Cystic fibrosis airway microbiome: overturning the old, opening the way for the new

GA O'Toole - Journal of bacteriology, 2018 - Am Soc Microbiol
The genetic disease cystic fibrosis (CF) is associated with chronic airway infections that are
a proximal cause of death in many patients with this affliction. Classic microbiology studies …

Antibiotic Management of Lung Infections in Cystic Fibrosis. I. The Microbiome, Methicillin-Resistant Staphylococcus aureus, Gram-Negative Bacteria, and Multiple …

JF Chmiel, TR Aksamit, SH Chotirmall… - Annals of the …, 2014 - atsjournals.org
Despite significant advances in treatment strategies targeting the underlying defect in cystic
fibrosis (CF), airway infection remains an important cause of lung disease. In this two-part …

The cystic fibrosis airway microbiome

SV Lynch, KD Bruce - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Repeated pulmonary exacerbation and progressive lung function decline characterize cystic
fibrosis (CF) disease, and represents one of the leading causes of mortality in this patient …