The authors studied the intrathecal IgM synthesis (ITMS) in paired sera and CSF samples
from 65 patients with MS, 28 with CNS infection, 40 with other neurologic diseases and eight …

Background: The authors have recently described that intrathecal IgM synthesis (ITMS)
correlates with a higher disability in patients with clinically definite MS (CDMS). Objective: To …

Abstract Objectives Intrathecally synthesized IgM can be seen not only in the cerebrospinal
fluid (CSF) in infectious and inflammatory diseases of the central nervous system, but also in …

Intrathecal IgM synthesis (ITMS) predicts a worse evolution in the first stages of multiple
sclerosis (MS). The aim of this study was the follow‐up of a group of relapsing‐remitting MS …

Immunoglobulin (Ig) M concentration in cerebrospinal fluid (CSF) was measured in 30
reference subjects to determine reference ranges which were up to 0.41 mg/l for CSF IgM …

The intrathecal synthesis of IgM, determined at clinical onset in patients with multiple
sclerosis, was found to correlate with the degree of disability (as evaluated by means of the …

Intrathecal IgM synthesis was assessed through the detection of oligoclonal bands in
cerebrospinal fluid (CSF) and through calculation of IgM index values and total CSF IgM …

The objective of this study was to investigate, whether the presence of oligoclonal
immunoglobulin M bands (IgM‐OCB) in cerebrospinal fluid (CSF) from patients with a …

Isoelectric focusing of CSF and serum IgG followed by crossed immuno isoelectric focusing
and direct immunofixation as well as quantitative assay of IgG and albumin were performed …

The level of IgM was determined by Particle Counting Immunoassay in the cerebrospinal
fluid. In non-neurological patients (N= 20) the mean was 97.5 μg/l with the upper reference …