was treated with/S-benzyl-L-aspartate9 in tetrahydro-furan-aqueous sodium hydroxide at pH
7-8 to give N-formylglycyl-^-benzyl-L-aspartate (III), mp 170,[a] D+ 6.7. NT rifluoroacetyl-O …

The occurrence of a single reactive serine residue in several proteolytic enzymes has
indicated that the peptide sequences containing this reactiveserine are close to, or at, the …

(XI) and Kenner lo). We chose to introduce the serine residue initially as the N-
benzyloxycarbonyl derivative with the side-chain hydroxyl unprotected and to attach the N …

March 1SJ67 Notes 251 with 300 ml of water, and then with 200 ml of acetone. The product
was collected and recrystallizedby dissolving in 500 ml of 1% NaOH solution, heating to …

The synthesis of acetylphenylalanine/3-naphthyl ester, phthalylphenylalanine/3-naphthyl
ester, nicotinylphenylalanyl-< 3-naphthylamide and nicotinylphenylalanyl-^-anisidide are …

The synthesis of the hexadecapeptide Tyr-His-His-Phe-Phe-Asp-His-Ser-Asp-Ser-His-Phe-
Asp-Phe-His-Phe was carried out by the solid-phase method. This large peptide was …

The synthesis of cyc/o-glycyl-L-histidyl-L-serylglycyl-L-histidyl-L-seryl, a possible model
enzyme, has been investigated. Improved methods for the synthesis of the tripeptide, glyeyl …

Based on the analyzed conformation of a chymotrypsin inhibitor H-▿ Phe-Phe-OMe, we
have designed a series of diastereomeric phenylalanylphenylalanine methyl esters and …

(Table I). Amino acid analyses11 of chymotrypsin and of the irreversibly inactivated
chymotrypsin show that one methionine residue in the latter is de-stroyed, and that the …

We are attempting to develop nev, epecifia reagent8 for locating the aatlve centers of
enzymes by designing molecule~ s which combine two klnda of structural features, namely …