The development of cancer cell resistance to various cytotoxic stimuli continues to be a
major challenge in oncology and novel therapeutic approaches are urgently needed. Nitric …

Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in
various physiological as well as pathological processes. Over past decades, NO has …

The recent developments on understanding the challenging topic of nitric oxide (NO) and its
derivatives in the field of cancer have yielded significant advances in the potential …

Metastasis is largely an unsuccessful process, because the majority of disseminating tumor
cells demise shortly after reaching distant organs. Therefore, survival is essential for …

Nitric oxide (NO˙) is a short-lived, endogenously produced gas that is highly diffusible across
cell membranes and acts as a signaling molecule in the body. The redox state and chemistry …

Recent evidence from experimental and clinical studies links the development of
intratumoral hypoxia and oxidative stress with malignant progression. Cellular adaptation …

Resistance to current therapeutic interventions is a major challenge in the treatment of
patients affected by cancer. While nitric oxide (NO) might have proneoplastic properties, it is …

Nitric oxide (NO) is an endogenous, multipotent biological signaling molecule that
participates in several physiological processes. Recently, exogenous supplementation of …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Nitric oxide (NO), a potent biological mediator, plays a key role in physiological as well as
pathological processes, including inflammation and cancer. The role of NO in tumor biology …